Endocrine Abstracts

Background: Insulinoma is a rare neuroendocrine tumor that causes inappropriate secretion of insulin resulting in hypoglycemia. The diagnosis of insulinoma may be difficult. Recurrence after surgery is rare and it usually concerns tumors with high histological grade.Case presentation: We report a case of a 52-year-old woman with recurrent episodes of symptomatic hypoglycemia. The laboratory investigations showed high insulin (20 IU/ml) and C-peptide leve...

Introduction: The insulinoma is a rare neuroendocrine tumor derived from the beta islet cell of the pancreas. It is usually sporadic and benign in 90% of the cases. It occurs more often in women in their fifties.Observation: We report the case of 76-year-old women with a medical history of hypertension and dyslipidemia, who was transferred to our department from the emergency unit after a diagnosis of severe episode of hypoglycemia (glucose level at 0.2 ...

Background: Adrenocortical carcinoma is a rare malignancy with a poor prognosis. Local recurrence is affected by the pathologic features (tumor staging and mitotic index) and the complete surgical resection. Treatment of a recurrent adrenocortical carcinoma can be a real challenge.Case description: We report a case of 47-year-old man who was operated for an adrenal tumor with bone metastases. Left adrenalectomy and splenectomy were performed and histolog...

Introduction: Ectopic pituitary adenomas (EPAs) are extremely rare intracranial tumors. Since 1909, few cases has been reported in the literature. We report a case of clivus prolactinoma.Case report: A 52-year-old women with a history of infertility, presented one year ago at the emergency with headaches and a sudden decreased visual acuity. The pituitary MRI revealed an arachnoidocele, pituitary adenoma of the left cavernous lodge measuring 20×18&#...

Introduction: Rathke cleft cysts (RCC) are benign cystic lesions of the sellar and suprasellar region, which is believed to arise from the remnants of the Rathke pouch. Symptomatic RCC are rare. Endocrine symptoms are usually caused by compression of the surrounding pituitarygland. It can therefore cause hypopituitarism, but it is rarely associated with primary endocrine dysfunctions. In this case, we report a co-occurrence of premature ovarian insufficiency and RCC.<p cla...

Background: Wolfram syndrome is an autosomal recessive neurodegenerative disease. It is secondary to the mutation of WFS1 gene. It combines a tetrad of pathologies known also as DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy and Deafness). Case presentation: We report a case of 31-year-old women with medical history of type 1 diabetes since the age of 3 years old. She suffered from decreased visual acuity since the age of 5 years old and t...

Introduction: Thyrotropin-secreting pituitary tumors (TSH-omas) are a rare cause of hyperthyroidism and account for 0.5 to 3 percent of all functioning pituitary tumors and much less than 1 percent of all cases of hyperthyroidism. The co-secretion of thyrotropin (TSH) and growth hormone (GH) in pituitary adenoma is extremely rare. Only a few cases have been reported.Observation: We report the case of a 40-year-old man who consulted an ophthalmologist for...

Hirsutism though common in women of reproductive age, is classically associated with polycystic ovarian syndrome (PCOS). It is rarely seen as a prominent feature of acromegaly because of its lack of specificity and occurrence. We report a case of 28-year-old female with 3 year duration of aligoamenorrhea and hirsutism. She was followed by a gynecologist who retains the diagnosis of polycystic ovary syndrome (PCOS). After 5 years the patient complaints of increased hand finger ...

Background: Pituitary apoplexy is a rare clinical syndrome due to abrupt hemorrhaging and/or infarction of the pituitary gland, generally within a pituitary adenoma. The outcome of acute apoplexy is variable and difficult to predict. This explains why the optimal management of acute pituitary apoplexy remains controversial. The aim of our study was to investigate the clinical, hormonal and radiological characteristics of pituitary apoplexy and to determine treatment outcomes.<...

A 38-year-old woman presented with symptoms suggesting Cushing’s syndrome. She has a history of surgery of mature ovarian teratoma (hysterectomy, ovarectomy) associated to radio and chemotherapy 15 years ago. The malignant teratoma relaps with hepatic and grelic metastases, and was unresectable. Main complaints were weight gain with centripetal fat distribution, muscle weakness, melanodermia and purpule striae on the skin of the abdomen, thighs, breasts and arms....